In acute leukemia, ETV6 is frequently involved in fusion with other genes, and for some fusions, the mechanism for leukemia is not the production of a functional fusion protein but rather affected gene expression, as we have previously shown for AML with t (7; 12)(q36; p13), resulting in the rearrangement of ETV6 and upregulation of MNX1 [11, 12]. Here, ETV6 is linked to acute myeloid leukemia.