STOX1‐A upregulation increased, while STOX1‐A downregulation decreased the oxygenized PTEN and phosphorylated AKT1 at Ser473 (p‐AKT1 (Ser473)) in HCC cells and reduced the reduction of PTEN but had no significant influence on total AKT1 expression (Figure 6C). The gene discussed is PTEN; the disease is hepatocellular carcinoma.