P2RX7 and infection: The P2X7 receptor belongs to the P2X purinergicfamily (P2X1–7)of trimeric nonselective cation channels gated by ATP. Among the P2X receptors, P2X7 is activated by high concentrationsof extracellular ATP (∼100 μM), which are usually presentin situations of cell death, such as infection and inflammation, whereit functions as a “death receptor”.−,