CDKN2A and pleural mesothelioma: Moreover, genetic predisposition and germline mutations in genes such as BAP1, CDKN2A/B, TP53, NF2, BRCA2, ATM and APC have been proposed to play a more prominent role in the pathogenesis of PeM than environmental factors do, in contrast to pleural mesothelioma, which seems to be more linked to environmental carcinogens.4, 5, 6, 7