KCNJ15 and Parkinson disease: Given that the basal ganglia, which regulate movement, rely on a balance between excitatory and inhibitory signals, diminished Kir4.2 function could disrupt this equilibrium, including chronic stress on neuronal networks and exacerbating PD's progression (Aron & Poldrack, 2006; Beste et al., 2010; Kumar et al., 2011).