Loss of Kir4.2 function may lead to increased neuronal excitability, resulting in higher energy demands, elevated mitochondrial activity, and excessive production of reactive oxygen species, factors known to contribute to PD‐related neurodegeneration (Drechsel & Patel, 2008; Orth & Schapira, 2002; Trist et al., 2019). The gene discussed is KCNJ15; the disease is Parkinson disease.