Concurrently, tumors promote leukocytosis, notably neutrophilia, through the release of pro-inflammatory cytokines such as IL-6 and granulocyte colony-stimulating factor (G-CSF), contributing to an elevated neutrophil-to-lymphocyte ratio (NLR), which is associated with poor prognosis [8]. The gene discussed is CSF3; the disease is Increased total leukocyte count.