The exploration of seronegative sicca syndrome—suffered by patients who present with xerostomia and/or keratoconjunctivitis sicca but lack anti-SSA/SSB antibodies and do not fulfill current classification criteria for primary Sjogren’s syndrome [2] (pSS)—reveals a clinical domain that is at once familiar and enigmatic. This evidence concerns the gene SSB and Keratoconjunctivitis sicca.