Additionally, most GBA1 carriers in our study had the mild N370S variant, which has a lower estimated conversion rate to PD (approximately 3–5-fold higher) compared to the non-N370S carriers (5–15-fold higher) [6,7], making detection of a statistically significant difference from the control population (risk of ~1% over age of 60 years) more challenging. Here, GBA1 is linked to Parkinson disease.