Active phosphorylated AKT (at S473) and active phosphorylated PKCδ (at T507 and S645) were positively correlated with phosphorylated glycogen synthase kinase GSK3α/β (S9/S21) protein expression levels in blast cells from de novo patients with AML, which reflects inactivation of the GSK3 kinase [72]. This evidence concerns the gene AKT1 and acute myeloid leukemia.