Therefore, Gal-3 was suppressed by lentiviral LGALS3 shRNA in two different AML cell lines, namely wt p53 OCI-AML3 and p53-null THP-1 cells, and subsequently treated with ABT-737, a BH3 mimetic agent targeting the anti-apoptotic proteins Bcl-XL and Bcl-2. The gene discussed is BCL2; the disease is acute myeloid leukemia.