LGALS3 and acute myeloid leukemia: Expression of the Wnt/β-catenin pathway target genes, such as cyclin D1 [114] and c-Myc [115], was increased in the hBM-MSCs-conditioned AML cell line, and was downregulated after Gal-3 silencing in the hBM-MSCs-conditioned AML cell line [107].