SMAD6 and acute myeloid leukemia: Among the nine proteins, Gal-3, phosphorylated β-catenin (p-CTNNB1; S33/S37/T41) and phosphorylated RPS6 were expressed at higher levels in BM-MSCs derived from relapsed/refractory patients with AML, while SMAD6, LYN, TCF4, integrin β3 (ITGB3), phosphorylated ELK1 and phosphorylated EIF4BP1 were higher in BM-MSCs derived from patients with AML at initial diagnosis [127].