Overexpression of miR-152 in glioblastoma stem cells reduced cell proliferation, migration, and invasion, but enhanced apoptosis by downregulating Krüppel-like factor 4 (KLF4) protein expression, which leads to inhibition of Gal-3 expression and MEK1/2 and PI3K signaling. This evidence concerns the gene MAP2K1 and glioblastoma.