Diffuse idiopathic skeletal hyperostosis (DISH)-derived BM-MSCs have a stronger osteogenic differentiation capacity than normal BM-MSCs, which may be due to the increased secretion of Gal-3 by DISH-BMSCs that activates the Wnt/β-catenin signaling by increasing β-catenin protein expression and its nuclear accumulation [147]. Here, LGALS3 is linked to diffuse idiopathic skeletal hyperostosis.