Gal-3 protein in AML-derived MSCs showed a positive correlation with the expression of thirteen proteins, including p-CTNNB1 (S33/S37/T41), Myc, CCND1 (cyclin D1), MAPK9, BAD, AKT2, CDK4, STAT1 and EGFR, while it negatively correlated with the expression of six proteins, including ITGB3, STMN1, LYN, and SIRT1. This evidence concerns the gene LGALS3 and acute myeloid leukemia.