Examples of activated pathways include PI3K/AKT/mTOR, Ras/Raf/MEK/ERK, JAK/STAT, JNK, Wnt/β-catenin, PLC/PKC and NF-κB, which are interconnected to promote AML cell survival and chemoresistance. This evidence concerns the gene AKT1 and acute myeloid leukemia.