Nevertheless, the expression of Wnt/β-catenin pathway target genes was not affected by Gal-3 silencing in the AML cell line cultured alone [107], which suggests that Gal-3 overexpression is needed to induce activation of the Wnt/β-catenin pathway and transcription of its target genes in the AML cell line. Here, LGALS3 is linked to acute myeloid leukemia.