GSK-3β activation by inactivation of PI3K/AKT also causes Mcl-1 instability and subsequent mitochondrial apoptosis when growth factors are removed [117], implying that Gal-3 may also induce AML cell survival by causing Mcl-1 stabilization via PI3K/AKT activation and then GSK-3β inactivation. The gene discussed is LGALS3; the disease is acute myeloid leukemia.