When Gal-3 binds to the NKG2D-binding site of MICA via the core2 O-glycans of MICA, the recognition of metastatic human bladder tumor cells by human NK cells is impaired, and the activation of NK cells is severely suppressed by a strong reduction in the secretion of IFN-γ and granzyme B [197]. This evidence concerns the gene KLRK1 and urinary bladder neoplasm.