A subset of SLC family members, including SLC3A2, SLC7A6, SLC7A11, SLC7A5, SLC7A8, SLC43A1, LCN2, SLC7A9, SLC7A7, BSG, and SLC7A10, are frequently overexpressed in multiple cancer types and are strongly associated with tumor progression, metastasis, and therapy resistance [5,6,7,8]. The gene discussed is SLC7A5; the disease is cancer.