The function and expression of these channels are regulated by various signaling pathways, accessory subunits such as KV4-channel-interacting proteins (KChIPs), and transcription factors such as restrictive neuron silencing factor (REST) [233,234], which, interestingly, suppresses the transcription of the KCND3 gene encoding KV4.3 channels after nerve injury [235]. This evidence concerns the gene REST and injury.