An alternative possibility to reduce the activity of KV2.1 channels that occurs in neuropathic pain is through the deregulation of KVS subunits, such as KV9.1, which participates in the formation of the functional tetrameric channel [227,230]; KV9.1 is the only KVS subunit implicated in the pathophysiology of neuropathic pain. Here, KCNS1 is linked to neuropathic pain.