Several studies support an important role of the interaction between the CaVα2δ-1 subunit and thrombospondin-4 (TSP4), a glycoprotein found in the extracellular matrix, in nerve-injury-induced neuropathic pain, mediated through aberrant excitatory synapse formation and presynaptic neurotransmission in the SC [150,151,152]. This evidence concerns the gene THBS4 and neuropathic pain.