Additionally, elevated IgE levels may be observed in numerous non-allergic conditions, including hematologic malignancies (e.g., IgE myeloma, Hodgkin lymphoma), immunodeficiencies (e.g., Wiskott–Aldrich syndrome, Job’s syndrome), parasitic infections, autoimmune diseases, and certain viral or bacterial infections [75]. Here, IGHE is linked to autoimmune disease.