SERPINE1 and Insulin resistance: In this direction, dysregulated adipocytes have been illustrated to release higher levels of inflammatory cytokines (IL-6 and IL-1β) and adipokines, including leptin, visfatin, resistin, angiotensin II, and plasminogen activator inhibitor-1 (PAI-1) [87], thus contributing to a low-grade inflammatory state and insulin resistance [86,88].