Among the Japanese cohort, Mitama et al. [23] found a significantly higher risk of fracture among T2D men and women with high C-reactive protein (CRP) compared with the non-diabetes group with a low CRP (in men, hazard ratio [HR] 1.47, 95% CI: 1.02–1.98; in women HR 1.41, 95% CI: 1.04–1.92). This evidence concerns the gene CRP and diabetes mellitus.