In women, crude incidence rates (IRs) for hip fractures, non-spine fractures, and major osteoporotic fracture (MOF) were not significantly different (age > 30) in patients with T2D that are not using insulin (IR hip: 8.7; 95% CI 6.8–11.0) or using insulin (IR hip: 11.1; 95% CI 6.8–18.0) compared with women without T2D (IR hip: 7.0; 95% CI 6.6–7.4) [30]. The gene discussed is INS; the disease is type 2 diabetes mellitus.