GLP1R and constipation disorder: Additionally, personalized medicine should be considered when planning interventions, particularly focusing on patients at higher risk of inadequate BP such as male patients with constipation, cirrhosis, diabetes mellitus, hypertension, stroke, or dementia [64] or those using medications like opioids, tricyclic antidepressants [64], and newer agents such as glucagon-like peptide 1 receptor agonists [11].