Two more well-identified risk factors are obesity (in our case expressed as high BMI) and malnutrition (in our case expressed as low albumin levels) [51,52], for which there is evidence that both share the same mechanisms to a certain extent (dysregulated immune function, impaired tissue oxygenation and regeneration, altered microbial environment, and prolonged inflammatory state). The gene discussed is ALB; the disease is obesity due to melanocortin 4 receptor deficiency.