CTLA4 and Sepsis: Immunomodulatory cytokines (IFN-γ, IL-7, -15, -33), growth factors (GM-CSF), thymosin-α, immune checkpoint inhibitors (PD-1/PD-1L, CTLA-4, LAG-3, TIM-1), administration of immunoglobulins, and cell therapy with mesenchymal cells are being studied for use in patients with sepsis [55,56].