MiR-122 regulates hypertension by modulating the renin–angiotensin system (RAS), endothelial dysfunction, vascular fibrosis, autophagy, pulmonary vascular remodeling, and fibrogenesis through pathways like Nuclear Factor Kappa B (NF-κB), Transforming Growth Factor Beta (TGF-β), β-catenin, Phosphoinositide 3-Kinase/Protein Kinase B (PI3K-Akt), and cationic amino acid transporter [18,19,20,21,22]. The gene discussed is AKT1; the disease is endothelial dysfunction.