Within the RA cohort, no significant differences were observed between male and female or between seronegative and seropositive patients, regarding age, disease activity measures (SJC, TJC, DAS28-CRP, DAS28-ESR), levels of CRP and ESR, or the proportions of RF or anti-CCP positivity between male and female patients. The gene discussed is CRP; the disease is rheumatoid arthritis.