Key prognostic factors influencing outcomes in patients undergoing pulmonary metastasectomy for colorectal cancer (CRC) include the disease-free interval (DFI) and preoperative carcinoembryonic antigen (CEA) levels, both of which are widely recognized as independent indicators of tumor burden and key guides for treatment planning [7,12,13]. The gene discussed is CEACAM5; the disease is neoplasm.