The identified at-risk groups for developing ASIA after receiving silicone implants include individuals with prior autoimmune reactions to adjuvants (e.g., vaccines, implants), those with established autoimmune conditions (e.g., Hashimoto’s disease, Graves’ disease, rheumatoid arthritis), individuals with a history of allergic or atopic disorders (e.g., eczema, pollen allergy, drug allergy), and those genetically predisposed to autoimmunity (e.g., HLA-DR4, HLA-DRB1) [8]. The gene discussed is HLA-DRB1; the disease is Autoimmunity.