CD177+ neutrophils confer protection in IBD by exerting potent antimicrobial activity while producing lower levels of pro-inflammatory cytokines (e.g., IL-6, IL-17A, IFN-γ) and higher levels of IL-22 and transforming growth factor-β (TGF-β), promoting tissue repair [28,37]. The gene discussed is IL22; the disease is inflammatory bowel disease.