In the elderly DFI population, the quantitative serum CRP level is dynamic and influenced by many inherent co-morbidities such as gout, cancer, rheumatic diseases, thrombosis, statin drugs, Charcot foot arthropathy [19], hematoma, ischemia, dialysis, cirrhosis, trauma, obesity, or being postoperative [9,20]. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.