Previous studies showed that adiponectin anti-inflammatory effects are mediated by the suppression of M1 macrophages, which promote pro-inflammatory factors and induce insulin resistance, stimulating M2 cells, enhancing the release of anti-inflammatory factors, such as IL-10, reducing the secretion of IFN-γ, IL-6, and TNF-α [53]. Here, ADIPOQ is linked to Insulin resistance.