GLP-1 RA and SGLT-2i offer an innovative and unique advancement in the treatment of T2DM by not only benefiting blood glucose control but also preventing, stabilizing, and improving other diabetes-related complications, including but not limited to, cardiovascular events, nephropathy, obesity, etc. [5,6,7,8,9,10]. Here, GLP1R is linked to type 2 diabetes mellitus.