ALB and Increased total leukocyte count: For advanced-stage HL, the International Prognostic Score (IPS) is widely used and incorporates seven variables: age ≥ 45 years, male gender, stage IV disease, hemoglobin < 10.5 g/dL, albumin < 4 g/dL, leukocytosis (≥15,000/mm3), and lymphocytopenia (<600/mm3 or <8% of the white blood cell count) [24].