EZH2 and Miyoshi myopathy: Furthermore, there is initial evidence suggesting that prolonged exposure to selinexor can lead to the increased immunogenicity of MM cells mediated by the expression of the Enhancer of Zeste homolog 2 (EZH2) and its catalytic role on the tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression.