MTHFR and hyperinsulinemic hypoglycemia, familial, 4: A thrombophilia workup was reported in 59 patients, revealing only five positive cases (homozygous MTHFR gene and heterozygous Factor V Leiden mutations, Protein C and S deficiency, HIT and LA hypercoagulability mutation, Inherited Protein S deficiency, and heterozygous PT20210Z gene mutation) [44,62,63,64].