BCHE and neurodegenerative disease: Additionally, Ajiboye et al. [10] verified that the ethyl acetate fraction from C. aconitifolius leaves significantly inhibited AChE (IC50: 61.13 μg/mL) and butyrylcholinesterase (BChE) (IC50: 56.25 μg/mL), suggesting potential use in cholinergic disorders and neurodegenerative diseases.