Among them, the primary signaling pathways might involve the PI3K-AKT signaling pathway, lipid and atherosclerosis, proteoglycans in cancer, Kaposi sarcoma-associated herpes virus infection, hepatitis B, endocrine resistance, prostate cancer, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, and central carbon metabolism. The gene discussed is AKT1; the disease is Familial prostate cancer.