CD8A and tuberculosis: The xCell analysis revealed distinct immune profile differences between LTBI and TB patients, with TB patients exhibiting higher proportions of innate immune cells such as monocytes, macrophages (M1 and M2), neutrophils, and dendritic cells, while showing lower proportions of adaptive immune cells, including CD4+ and CD8+ T-cell subsets, Natural Killer cells, and B-cell populations (Figure 3A).