An association with cancer has been shown for almost all of these genes, namely, FICD gene is associated with CRC [41]; UBE3B, with breast cancer [65]; PWP1, with non-small cell lung cancer [66], gastric cancer [67], and hepatocellular carcinoma [68]; PRDM4, with gastric cancer [69], prostate cancer [70], and cervical carcinoma [71]; and TMEM119, with osteosarcoma [72], ovarian cancer [73], breast cancer [74], and non-small cell lung cancer [75]. The gene discussed is TMEM119; the disease is osteosarcoma.