Chromosome 22q harbors multiple tumor suppressors and apoptosis-related genes (e.g., APOBEC3B, CHEK2, CLTCL1, EP300, LZTR1, MKL1, MYH9, NF2, ATF4, MAPK1, MAPK12, CARD10, and XRCC6). This evidence concerns the gene ATF4 and neoplasm.