Other immune-related genes that can contribute to the genetic predisposition to AD include IL-4R, IL-13R, IL-31, IL-33, signal transducer and activator of transcription (STAT) 6, thymic stromal lymphopoietin (TSLP) and its receptors (IL-7R and TSLPR), interferon regulatory factor 2, Toll-like receptor 2 and the high-affinity IgE receptor (FcεRI) α gene in specific populations [33]. Here, IL31 is linked to Alzheimer disease.