AD: Alzheimer’s disease; DLPFCTX: dorsolateral prefrontal cortex; BMI: body mass index; HDL: High-density lipoprotein; TL: telomere length; mtDNA-CN: mitochondrial DNA copy number; Aβ: amyloid beta peptide; DunedinPACE: Dunedin Pace of Aging calculated from the epigenome; HC: hippocampal grey matter volume; CT: cortical thickness; MCI: mild cognitive impairment; GWAS: Genome-Wide Association Study; IEAA: intrinsic epigenetic age acceleration. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.