TIGD1 and central nervous system cancer: Cox regression analysis identified TIGD1 as a risk factor for poor prognosis in acute myeloid leukemia, the pan-kidney cohort, colon adenocarcinoma, the colorectal cohort, kidney renal clear cell carcinoma, liver hepatocellular carcinoma, and adrenocortical carcinoma, whereas it showed a protective role in the combined glioblastoma and lower-grade glioma cohort and lower-grade glioma (Figure 5a).