Additionally, it evaluates the prognostic and diagnostic significance of TIGD1 across different tumor types while exploring its role in immune regulation, particularly its interactions with immune checkpoint molecules, tumor mutational burden (TMB, the total number of mutations per megabase of tumor DNA), and microsatellite instability (MSI, a condition of genetic hypermutability resulting from impaired DNA mismatch repair). The gene discussed is TIGD1; the disease is neoplasm.