Notably, TIGD1 expression emerged as a promising diagnostic marker in kidney chromophobe (KICH; AUC = 0.770), testicular germ cell tumors (TGCTs; AUC = 0.783), thyroid carcinoma (THCA; AUC = 0.864), and thymoma (THYM; AUC = 0.754), indicating particularly high diagnostic performance in these malignancies (Figure 4). The gene discussed is TIGD1; the disease is testicular germ cell tumor.