While ADPKD is predominantly associated with PKD1 and PKD2 gene variants, there are documented cases where individuals with pathogenic variants in COL4A3, COL4A4, or COL4A5 also present with renal cysts and even a clinical diagnosis of polycystic kidney disease (PKD) [13]. This evidence concerns the gene COL4A3 and autosomal dominant polycystic kidney disease.