SOD1 and amyotrophic lateral sclerosis: To prove the importance of miR-206, the team bred miR-206−/− mice expressing a low copy number of SOD1 G93A, and it was found that the loss of miR-206 accelerated disease progression and reduced survival by one month but did not affect disease onset; additionally, the initial progression of ALS was the same between SOD1 G93A miRNA 206−/− transgenic mice and SOD1 G93A mice [27,30].