ATP2A2 and Parkinson disease: Considering that SERCA2 dysfunction in Darier’s disease (DD) leads to intracellular calcium accumulation and TRPC1 overexpression [97], and that similar mechanisms of calcium dysregulation have been implicated in Parkinson’s disease (PD), it is plausible that these shared pathways contribute to DD patients’ increased risk of being diagnosed with PD [98].