ATP2A2 and hypertrophic cardiomyopathy: For instance, a study comparing the proteomic profiles of human hypertrophic cardiomyopathy found 88 differentially expressed proteins related to both contraction mechanisms, which included the downregulation of sarcomeric proteins MYH6 and MYBPC3, as well as the downregulation of metabolic proteins, including creatine kinase and the sarcoplasmic reticulum calcium transport protein ATP2A2 [75,76].