Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas, causing Cushing’s disease (CD), have been found to be causal factors for persistent hypercortisolism, which is preferably treated with transsphenoidal surgery (TSS), and have been observed to be associated with immunosuppression, diabetes, hypertension, osteoporosis, and higher mortality rates. This evidence concerns the gene POMC and hypertensive disorder.