From January 2013 to February 2023, a total of 50 patients, comprising 34 females (69.7%) and 16 males (30.2%), with a median age of 37.8 years and a range of 15–69 years, underwent removal of an ACTH-secreting pituitary adenoma through the endoscopic endonasal approach. Here, POMC is linked to pituitary gland adenoma.