Furthermore, c.3421C>T in ABCC6 plays a role in vascular calcification in chronic kidney disease (CKD) [19,29], and its association in heterozygous state with ischemic heart disease has been demonstrated in some case–control studies [20,21,30,31] (though it was not confirmed in further meta-analysis study) [22,32]. The gene discussed is ABCC6; the disease is chronic kidney disease.