This report presents a unique case of a child with familial DCM, caused by a pathogenic nucleotide variant in MYH7, and AC, caused by pathogenic nucleotide variants in ABCC6 gene, identified by targeted next-generation sequencing (NGS) of a panel of 404 genes, which is a perfect example of such a scenario. This evidence concerns the gene ABCC6 and familial dilated cardiomyopathy.