Similarly, PLEC mRNA and protein expression were also positively associated with carboplatin AUC (Figure 8E,G) and paclitaxel AUC (Figure 8F,H) in all cancer cell lines Data from the GSE45553 database showed the expression of COL12A1, PLEC, and TKT in cisplatin-resistant OVCAR-8 spheroids were significantly increased compared to OVCAR8 control spheroids, also supporting a role for COL12A1, PLEC, and TKT in chemotherapy resistance (Supplementary Figure S3). The gene discussed is TKT; the disease is cancer.