SHH and ovarian carcinoma: Comparing non-metastatic and metastatic ovarian cancer cell lines, the expression level of SHH and PTCH2 was significantly higher in the primary line CAOV-3 (p-value < 0.05) than in the metastatic line SKOV-3, while the expression level of GLI1 and GLI2 was higher in the metastatic line SKOV-3, as demonstrated in Figure 7.