To assess their potential prognostic value, we analyzed the correlation between the expression levels of the following eight components of the Hedgehog signaling pathway on the progression-free (PFS) and overall survival (OS) in ovarian cancer: SHH, GLI1, GLI2, GLI3, PTCH1, PTCH2, HHAT, and SUFU. This evidence concerns the gene PTCH2 and ovarian carcinoma.