In fact, ALK- ALCL and related CD30+ ALK− T-cell lymphoproliferative disorders involving the lymphatics are part of the expanding spectrum of CD30+ T-cell lymphoproliferative disorders Lymphatic vessels express CD31 and are negative for CD34, in contrast to intravascular T-Cell Lymphoma, which affects blood vessels and may also show CD30 positivity [283]. The gene discussed is TNFRSF8; the disease is T-cell non-Hodgkin lymphoma.