TP53 and anaplastic large cell lymphoma: Losses at 17p13 (42%) and at 6q21 (35%), which encode the TP53 and PRDM1 genes (the latter playing a tumor-suppressor role in ALCL models, in which it probably acts as an antiapoptotic gene, coding for BLIMP1), respectively, have also been observed in 52% of cases [85,172,173].