Several genes of interest, located in the following regions, may be involved in the pathogenesis: RAB38 (11q14), CXCL1, CXCL2, CXCL3, CXCL5 (4q13), CXCL9, CXCL10, CXCL11, CXCL13, MAPK10 (4q21), TP53 (mutated in 11% of ALK+ ALCL cases) [88,89], PIK3R5, PIK3R6, MAP2K3, MAP2K4 and USP22 (17p). This evidence concerns the gene ALK and anaplastic large cell lymphoma.