ALK- ALCL is a genetically heterogenous entity that encompasses diverse molecular subtypes with respect to the presence or absence of specific translocations of distinct prognostic significance: DUSP22 rearrangements (DUSP22Rs), TP63 rearrangements (TP63Rs) and Triple-Negative (TN, with all absent). This evidence concerns the gene TP63 and anaplastic large cell lymphoma.