Patients diagnosed with LIP patterns on high-resolution CT scan images presented a significant association with the concomitant positivity for all four immunological markers that were searched (anti-SSA/Ro antibodies, anti-SSB/La antibodies, RF, and ANA)—p = 0.03—suggesting that quadruple positivity might represent a risk factor for developing LIP in pSjD patients. This evidence concerns the gene SSB and oral cavity neoplasm.