Both titres (p = 0.07) and positivity rate—p = 0.09, OR 0.15 (0.01–1.63)—of anti-SSB/La antibodies registered a close-to-significance decrease in patients with UIP pattern, suggesting a possible protective role of these autoantibodies against this type of ILD. This evidence concerns the gene SSB and idiopathic pulmonary fibrosis.