Preliminary analyses integrating TCGA data tentatively propose that CPS1 in lung cancer might not only represent a candidate biomarker, as suggested by prior investigations, but could potentially correlate with radiotherapy efficacy and treatment-related prognostic outcomes, whereas the observed differential expression patterns of LOC401312 between histologically normal adjacent tissues and neoplastic lesions may hypothetically inform biomarker-driven approaches for refining therapeutic radiation protocols in clinical management. Here, CPS1 is linked to lung carcinoma.