ESR2 and endometriosis: miR-22-5p is downregulated in women with endometriosis, leading to increased Tet methylcytosine dioxygenase 2 (TET2) activity and altered methylation of genes like the progesterone receptor, HOXA10, and Estrogen Receptor 2 (ESR2), which contributes to progesterone resistance and implantation failure [30].