Notably, prunin, a citrus-derived flavonoid glycoside, has demonstrated potent anticancer activity by modulating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and Wnt/β-catenin pathways in breast and colorectal cancers [5]. The gene discussed is AKT1; the disease is colorectal cancer.