Beyond neurodegenerative conditions, cardiovascular pathologies involve context-specific tsRNAs: rno-tsr007330 modulates myocardial fibrosis via NAT10-mediated EGR3 mRNA acetylation [136], while tRNA-Cys-5-0007 reduces ocular angiogenesis and inflammation by targeting the 3′-UTR region of VEGFA and TGF-β1 to inhibit expression [137]. The gene discussed is EGR3; the disease is Myocardial fibrosis.