METTL1 and osteosarcoma: Similarly, METTL1/WDR4-mediated tRNA m7G modification enhances osteosarcoma progression and chemoresistance by altering oncogenic mRNA translation [106], while METTL1 depletion reduces m7G-modified tRNA levels in esophageal squamous cell carcinoma, impairing translation of oncogenic transcripts in the RPTOR/ULK1/autophagy axis [107].